Black Earth Zeolite Clinoptilolite with humic fulvic minerals

NEW! Now available in a 1 oz. convenient spray!

The company is the world’s best Clinoptilolite Mineral In bulk supplier. We are your one-stop shop for all needs. Our staff are highly-specialized and will help you find the product you need.

Black Earth® Zeolite has been used by natural health experts for over 10 years.  Sold exclusively in health practitioners offices originally, it is today also found in the finest health food stores in the nation.

AWARD WINNING ZEOLITE – Black Earth® is a highly purified extract of  Zeolite Clinoptilolite in a based of humic and fulvic minerals.  Every batch is third-party tested & very safe, produced in USA exclusively by the Food Movement Natural Products Company. 

MADE WITH HUMIC & FULVIC ACID – Black Earth® supplement contains both Humic Acid and Fulvic Acid.  Both of these organic acids have been shown to have numerous health benefits to the human body.* Fulvic Acid is a rich source of additional oxygen for the body.* These black minerals from the Earth make mineral compounds like Zeolite more usable, and more readily available to the cells of the body.*

CONTAINS OVER 70 TRACE MINERALS - Black Earth® contains a broad spectrum on naturally-occuring purified trace minerals from the Earth.  Many natural health experts believe this is the best way to remineralize your body on a cellular level!*

PROMOTES ACID-ALKALINE BALANCE - Black Earth® is a unique formula that contains not only Zeolite (in a purified water extract of Clinoptilolite minerals) but also the Humic & Fulvic Acids, as well as the broad array of trace minerals that help maintain proper pH balance in the bloodstream and at a cellular level.*

 

THIRD PARTY TESTED - Black Earth®  is produced in a Good Manufacturing Practices compliant facility in the USA, as stipulated by US regulations.  Every batch is tested by an independent laboratory to ensure safety and efficacy.*

 

  *These statements have not been evaluated by the FDA.  This product is not intended to prevent, treat, cure or diagnose any disease or medical condition.

1. Introduction

2,3. These metals adversely affect the environment and living organisms. Generally, they are considered toxic, depending on the chemical species, dose and route of exposure, as well as on the age, gender, pharmacogenetics and nutritional status of exposed persons. Of the metals, arsenic (As), cadmium (Cd), chromium (Cr) and lead (Pb) are highly dangerous [

Metals are ubiquitous and naturally occurring in the Earth’s crust and atmosphere, but their concentrations have recently risen to extreme levels in the environment. This is to a great extent a byproduct of human activities such as agriculture, heavy industry, transport, cosmetics, natural medicaments and the beauty industry [ 1 3 ]. Of particular concern is the highly increased abundancy of heavy metals, characterized by high atomic weight and a density of at least 5 g/cm. These metals adversely affect the environment and living organisms. Generally, they are considered toxic, depending on the chemical species, dose and route of exposure, as well as on the age, gender, pharmacogenetics and nutritional status of exposed persons. Of the metals, arsenic (As), cadmium (Cd), chromium (Cr) and lead (Pb) are highly dangerous [ 4 ]. Considered as systemic toxicants, they are capable of inducing multiple organ damage even at low concentrations, primarily by the induction of oxidative stress and mitochondrial damage [ 4 5 ].

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Metal toxicity can be acute or chronic, depending on the absorbed dose, and the route and duration of exposure. Even though prolonged exposure to low quantities of heavy metals and even aluminum (Al), classified as a light metal, in the short-term are not considered to be generally noxious (e.g., via cosmetics), various toxic effects including allergic contact dermatitis or systemic toxicity have been documented [ 6 ]. A few metals can be removed from living organisms by metabolic elimination (e.g., Al), but the majority of metals accumulate in the body, imposing a long-term health risk. Mechanistically, they bind to proteins by displacing original metals from their natural bidding sites and cause the malfunctioning of proteins, cells and tissues. The oxidative deterioration of biomolecules is primarily due to the binding of metals to DNA and nucleic proteins [ 7 ]. Consequential health perturbations may include osteoporosis, carcinogenesis, neurodegeneration, oxidative stress, endocrine disruption, DNA damage and immune system deterioration, organ failure and disturbances in reproduction [ 2 10 ].

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Although the individual health hazards of Pb, Cd and mercury (Hg) exposure are extensively studied, more attention should be given to the examination of their synergistic effect, since combined exposure to these toxicants in environmentally relevant concentrations causes damage to multiple organs as well as impairment of the neurobehavioral functions of rats [ 11 12 ].

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Several metals are considered essential and nutritionally valuable, since they play an important role in human physiology. Other metals, often referred to as heavy metals, such as As, Cd and Pb, are common food contaminants, with unknown biological functions and considerable negative impact on human health [ 1 14 ]. Some biological consequences documented for heavy metals include inflammation, oxidative stress, endocrine disruption and intestinal disorders correlated with gut microflora perturbations, and compositional and metabolic profile changes. Probiotic strains and their enzymes may help in the alleviation of these effects [ 15 ]. Some trace minerals (also belonging to metals) exhibit beneficial effects in vivo and may ameliorate metallic toxicity. One such element is selenium (Se), which sequesters As and Cd and incorporates them into inert complexes. Moreover, Se induces the erythroid 2-related factor 2 (Nrf2) pathway. This highly biologically active protein is a potent regulator of metallic toxicity. It triggers protective oxidative stress mechanisms through the release of antioxidants [ 16 17 ].

Importantly, the basic harmfulness to health of Al mainly arises from its pro-oxidant activity and consequential oxidative stress that leads to degradation of cellular proteins and lipids. Chronic excessive exposure to Al may provoke oxidative stress, tissue inflammation, genotoxicity, carcinogenesis, teratogenesis, tissue necrosis, endocrine disruption, diabetes onset, obesity, inhibition of cartilage and bone formation, hypertension, ischemic stroke and thrombosis [ 18 ]. Circulating Al is usually bound to transferrin, which seems to potentiate Al entrance in the central nervous system in a manner similar to iron [ 19 ]. Accordingly, increased Al levels in the brain are detrimental, and high interconnections of Al deposition in the brain are in correlation with neurotoxic effects, pathogenesis of Alzheimer disease [ 20 21 ] and autism spectrum disorders [ 22 ]. Thus, Al detoxification might be considered as a possible therapeutic approach in these conditions, as already seen in patients with Alzheimer’s disease [ 23 ].

Arsenic toxicity emerges from its extensive binding affinity and inhibition of selenoenzymes, which are known scavengers of reactive oxygen species [ 24 ]. This causes multiple changes in cell behavior through alterations in signaling pathways and epigenetic modifications, as well as direct oxidative damage to proteins and lipids [ 25 ]. Acute As poisoning causes abdominal pain and gastrointestinal problems [ 26 ]. Prolonged As exposure may cause skin lesions, development of neoplasms, peripheral neuropathy, cardiovascular disease and neurodevelopmental problems [ 24 ]. However, in addition to its toxic effect, As has certain beneficial medical properties. Specifically, As trioxide greatly improves the survival of patients suffering from acute promyelocytic leukemia [ 27 ]. Such applications fall into a specific and controlled medical therapy field.

Cadmium possesses no known biological function in humans, but has a very low rate of excretion and tends to accumulate in organs (e.g., brain, liver, kidney and testes), causing their impairment. It reduces the reproduction of both sexes even at low doses [ 28 ]. Its strongest toxic effects are seen in kidneys. Cd tends to accumulate in this organ as a result of its preferential uptake by receptor-mediated endocytosis in the proximal tubules. This triggers proteinuria, which can progress to renal Fanconi syndrome and eventually renal failure [ 29 30 ]. To exert the toxic effect, Cd must enter the intracellular space [ 31 ], where it triggers oxidative, apoptotic, spermal and steroidogenic toxicity [ 32 ]. Moreover, this metal exerts immunomodulatory function, and can trigger the release of chemokines, regulate gene expression and attenuate inflammation [ 33 ]. Although extensive research is being conducted, no efficient Cd antidotes are available for clinical application so far [ 34 ].

2+ upon prolonged excessive exposure to this element seems to underlie cobalt-induced chronic poisoning [

Cobalt (Co) is biologically relevant for the formation of vitamin B-12, but excessive exposure to this metal correlates with some pathological conditions such as the development of reduced thyroid activity, interstitial pulmonary fibrosis and cardiomyopathy [ 35 ]. Humans are usually exposed to Co via four distinct routes: occupational, environmental, dietary and medical. Of these, oral intake and internal exposure through hip implants are the most common medical hazards for the development of Co systemic toxicity. The release of free ionic Coupon prolonged excessive exposure to this element seems to underlie cobalt-induced chronic poisoning [ 36 ]. In microorganisms, Co is highly receptive to iron sulfur proteins, and, perturbing iron homeostasis, it incites oxidative stress [ 37 ].

Lead is not biodegradable, and when absorbed in organisms, it accumulates in blood, bones, liver, kidney, brain and skin. Negative effects on the reproductive, hepatic, endocrine, immune and gastrointestinal systems have been reported in humans [ 38 ]. Pb possesses strong affinity for sulfhydryl groups and electron donor groups. Thus, it tightly binds to various proteins, causing multiple harms to the affected individuals. It also competes with nutrients such as calcium (Ca) or zinc (Zn) in various important mechanisms which are usually mediated by their ions. Pb easily crosses cell membranes, exerts redox reactions and induces the formations of reactive oxygen species [ 39 ]. Thus, the toxic effects of Pb are quite complex and affect virtually all organs [ 40 ]. In adults, it can increase blood pressure, slow nerve conduction or induce fatigue, mood swings, drowsiness, impaired concentration, infertility, decreased libido, headaches, constipation or encephalopathy, or even cause death in severe cases [ 41 ]. Chronic exposure in early childhood causes adverse neurodevelopmental consequences even at low levels [ 42 ], and multi-organ damage or even death at high doses [ 43 44 ].

The hazard posed by nickel (Ni) to human health originates primarily from the production of free radicals, generation of the superoxide anion and reactive oxygen species. The consequential oxidative stress triggers genotoxicity, carcinogenicity and immunotoxicity [ 45 ]. Additional hazard mechanisms of Ni toxicity include competition with essential metals in metalloproteins or binding to enzymes and inhibition of their activity [ 46 ]. Ni is shown to induce various pathophysiological processes in humans, including those involved in the development of allergy, cardiovascular and kidney diseases, lung fibrosis, and pulmonary, nasal and sinus cancer. This metal is associated with epigenetic effects, namely DNA hypermethylation and histone ubiquitination, which are the key mechanisms associated with tumor initiation, cancer progression and metastasis [ 47 ].

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Strontium (Sr) is a trace element in the human body but has never been proved to be essential. Interestingly, the toxic effects of Sr overdose have not been reported in humans [ 48 ]. This mineral naturally accumulates in mineralized tissues by surface exchange or ionic substitution mechanisms. However, the exaggerated accumulation of Sr in bone is shown to be associated with development of osteomalacia in dialysis patients [ 49 ]. This element exerts remarkable osteogenic potential since it promotes bone formation and inhibits bone resorption. Thus, it has been incorporated in various orthopedic devices to enhance bone regeneration, especially in osteoporotic patients, where it improves bone mineral density [ 50 53 ].

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Special consideration has to be given to the potential of zeolites’ usage for the removal of metal pollutants. These naturally occurring, highly-porous minerals, also known as molecular sieves, show enormous capacity to eliminate metals from polluted environments, mainly by mechanisms known as ion-exchange and adsorption [ 54 55 ]. This property has been proved for zeolite clinoptilolite in both animals and humans [ 56 ]. The crystalline structure of these aluminosilicates has cavities filled with cations and polar molecules, such as water. These chemical entities are released from the structure and simultaneously substituted by chemical species from the environment, depending on their zeolite binding affinity [ 57 ]. Moreover, zeolite clinoptilolite is highly inert and safe for human utilization [ 58 ]. Both the preclinical and clinical literature imply the great medical potential of this material in the treatment of various diseases [ 58 60 ]. The volcanic mineral zeolite clinoptilolite is the most widely used natural zeolite in medicine. Prior to usage, it is usually activated by grinding into fine powder. In this process, its active surface and activity increase substantially [ 61 ]. Certain types of clinoptilolites have already been certified for clinical usage [ 56 ]. One such certified material, therefore determined as safe for oral human applications, is PMA (Panaceo-Micro-Activated) zeolite, with its detoxifying, antioxidant and anti-inflammatory properties [ 62 ].

In this work, we examined the in vivo efficiency and safety of the long-term oral administration of zeolite clinoptilolite materials in natural and activated forms. We intentionally used an excessively high dose of this zeolite (8 g/kg) to examine its effect on high metallic biodistribution in vivo. Our focus was on the measurement of the concentration profiles of Al and several contaminants (As, Cd, Co, Pb, Ni and Sr) in healthy rats fed with zeolite clinoptilolite materials. Metal concentrations were measured in the brain, gastrointestinal and excretory systems, bones and circulation systems of the animals.

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