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The GRANUMEIST® (GMX) High Shear Granulator Mixer systems have long been a staple in the pharmaceutical industry. Designed for efficient and homogeneous wet granulation of powders, these systems facilitate the creation of medium to high-density granules with outstanding flowability and compressibility properties. High-shear mixers serve essential roles across various sectors, including adhesives, chemicals, cosmetics, food, pharmaceuticals, and plastics, primarily for tasks like emulsification, homogenization, particle size reduction, and dispersion.

Whether you are a novice or a veteran in the material processing sector, this guide will be invaluable in your quest for a high shear granulator.

Applications for High Shear Mixer Granulators

The primary application of high shear mixers lies in mixing, granulating, humidifying, homogenizing, and processing pharmaceutical materials, accommodating both dry and wet powders.

Main Parts of The High Shear Granulation Machine

The quantity of components and designs may vary according to the machine type. Evaluating these elements is vital to ensure the machine meets various performance standards and requirements.

Key components of this granulation equipment include:

• Mixing Impeller
• Cylindrical Mixing Bowl
• Chopper
• Discharge Port
• Motor to Drive the Impeller
• Spray Nozzle for Binding Liquid
• Compressed Air
• Control System

Types of High Shear Mixer Granulators: Lab Scale to Production!

We offer two styles of GRANUMEIST® granulators: GMX Top-Drive and GMXB Bottom-Drive systems. Top-Drive mixers enter through the top/lid, while Bottom-Drive mixers access through the bottom and sides of the bowl. Both series can work with aqueous and solvent processing and include explosion-proof configurations up to 12-Bar pressure.

Design Considerations for Granulators

Evaluating designs should encompass various elements, such as:

• Granulation Container
• Impeller Design
• Chopper Design
• Sealing Mechanism
• Drive Mechanism
• Granules Discharge
• Machine Frame and Structure
• Granules Milling
• Spraying Nozzle
• Electrical and Control Panel

Example: Structure and Frame of the Freund-Vector GMX(B) High Shear Granulator Mixer

• Our equipment utilizes high-quality 316 stainless steel for all parts in contact with the product.
• This choice is vital for achieving cGMP compliance standards.

Choosing Between Three-blade or Two-blade Impeller Design

• Three-blade impellers require higher rotational speeds, potentially leading to thermal stressing, but yield dense granules.
• Two-blade impellers with elongated side wings offer rapid mixing at lower speeds.

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Importance of Accuracy in Granulation

It is imperative to maintain precision in pharmaceutical material processing. The design should promote uniform granulation, ensuring produced granules are strong and well-rounded.

The cylindrical mixing bowl must accommodate a diverse range of batch sizes, which prevents the need for additional equipment and minimizes time spent changing components. Freund-Vector caters to batch capacities from 1L upwards.

Regulatory Compliance

All equipment must exhibit adherence to stringent quality manufacturing protocols. cGMP regulations enforce the necessity for tight seals within the machinery. Freund-Vector implements non-inflatable seals, which enhance ease of cleaning and puncture resistance during operation.

The Working Principle of High Shear Mixer Granulator

Upon activation, the granulator undertakes the following processes:

• Dry Blending/Mixing the Powder
• Binder Addition (Granulation Liquid)
• Formation of Wet Powder
• Granules Begin to Form
• Densification of Powder
• Attrition and Breakage of Granules

Features of Granulation Machines

High shear granulators incorporate diverse technologies, ensuring operational reliability and efficiency. For example, Freund-Vectors Color Touch Screen Control System and upgradable COMPU system are optimal for various applications.

• Validatable Control System
• Automatic (Recipe-Driven) and Manual Modes
• Data Collection Port
• Multiple End-Point Detection Parameters
• COMPU Control System (Optional)

Factors Impacting Powder Granulation Quality

A quality machine alone does not guarantee successful granulation. Several factors may directly or indirectly influence the final granule formation. Key considerations include:

• Physical and Chemical Properties of the Powder
• Material Loading
• Types and Quantity of Binder Solution
• Granulation Solution Application Rate
• Impeller and Chopper Speeds
• Design of Granulator Machine

Advantages of Powder Granulation Machines

• Accelerated Powder Granulation Process
• Accurate and Precise Granule Production
• Minimal Binder Solution Requirement
• Reduced Powder Drying Time
• Consistent Production Process
• Increased Densification, Resulting in Less Friable Granules
• Easy Scale-Up

Conclusion

Interested in High Shear Mixers? Contact us to explore why our high shear mixers are an excellent choice for granulation equipment, providing fast and reliable processes crucial for powder particle agglomeration, whether for further processing or final products.

For additional information on leftover material crusher manufacturers, please contact us for professional guidance.